Abstract the extracellular matrix is a complex chemically and physically crosslinked network of proteins and glycosaminoglycans this matrix serves to organize cells in space to provide them with environmental signals to direct site specific cellular regulation and to separate one tissue space from another. Overview of how cells interact with the extracellular matrix if youre seeing this message it means were having trouble loading external resources on our website if youre behind a web filter please make sure that the domains kastaticorg and kasandboxorg are unblocked. The extracellular matrix ecm is an intricate network composed of an array of multidomain macromolecules organized in a cell tissue specific manner components of the ecm link together to form a structurally stable composite contributing to the mechanical properties of tissues the ecm is also a . Basal lamina the extracellular matrix proteins of the basal lamina also play an important role in the structure and function of the bbb these proteins serve as an anchor for the endothelium via interactions between laminin and other matrix proteins and endothelial integrin receptors
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